3,4-Dihydroxy-3-cyclobutene-1,2-dione CAS NO.2892-51-5

Specification The Squaric acid is an organic compound with the formula C4H2O4. The IUPAC name of this chemical is 3,4-dihydroxycyclobut-3-ene-1,2-d…

Specification The Squaric acid is an organic compound with the formula C4H2O4. The IUPAC name of this chemical is 3,4-dihydroxycyclobut-3-ene-1,2-dione. With the CAS registry number 2892-51-5, it is also named as 1,2-Dihydroxycyclobutene-3,4-dione. The product's categories are cyclic Compounds; Organic Acids; Cyclobutanes & Cyclobutenes; Simple 4-Membered Ring Compounds; Ring Systems. Besides, it is a white powder, which should be stored in a closed cool and dry place. Medically, squaric acid dibutylester is used for the treatment of warts. Squaric acid dibutylester is also used treating alopecia areata or alopecia totalis/universalis (autoimmune hair loss) through topical immunotherapy involving the production of an allergic rash. Physical properties about Squaric acid are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 4; (6)#H bond donors: 2; (7)#Freely Rotating Bonds: 2; (8)Polar Surface Area: 74.6 ?2; (9)Index of Refraction: 1.872; (10)Molar Refractivity: 21.485 cm3; (11)Molar Volume: 47.225 cm3; (12)Polarizability: 8.517×10-24cm3; (13)Surface Tension: 235.742 dyne/cm; (14)Density: 2.415 g/cm3; (15)Flash Point: 119.84 °C; (16)Enthalpy of Vaporization: 56.725 kJ/mol; (17)Boiling Point: 250.963 °C at 760 mmHg; (18)Vapour Pressure: 0.003 mmHg at 25°C. Preparation: this chemical can be prepared by N1-(2-Chlor-3,4-dioxo-1-cyclobutenyl)-N1,N2-diphenylchlorformamidin. This reaction will need reagent H2O and solvent dioxane. The reaction time is 14 days at ambient temperature. The yield is about 66%.